SARS-CoV-2 is a kind of 'smart' virus that generates complex and dynamic crosstalk with hosts.Even with thousands of publications,the researchers have only uncovered the 'iceberg' of the virus-infectious properties as well as its effects on human beings,and the approaches against the virus and the related pandemic are limited.In this special issue,several latest publi-cations provide new insights into the relationship between SARS-CoV-2 and its hosts and also de-liver potential methods to fight the infectious disease.