Diabetic patients with COVID-19 need more attention and better glycemic control

• 作者: Jun Zhou Ming Xu Tao Huang Wen Yang
• 来源期刊: 世界糖尿病杂志:英文版(电子版)
• 学科: 医学
• 关键词: DIABETES COVID-19 COMORBIDITY SEVERITY Glycemic control Hepatic dysfunction
• 年，卷（期）: 2020,（12）
• 页码范围: 644-653
• 页数: 10页
• 分类号: R58

摘要

BACKGROUNDCoronavirus disease 2019 (COVID-19) is a pandemic disease spreading all overthe world and has aroused global concerns. The increasing mortality has revealedits severity. It is important to distinguish severe patients and provide appropriatetreatment and care to prevent damages. Diabetes is reported to be a commoncomorbidity in COVID-19 patients and associated with higher mortality. Weattempted to clarify the relationship between diabetes and COVID-19 patients’severity.AIMTo determine the role of type 2 diabetes in COVID-19 patients.METHODSTo study the relationship between diabetes and COVID-19, we retrospectivelycollected 61 patients’ data from a tertiary medical center in Wuhan. All thepatients were diagnosed with laboratory-confirmed COVID-19 and admitted tothe center from February 13 to March 1, 2020. Patients’ age, sex, laboratory tests,chest computed tomography findings, capillary blood glucose (BG), andtreatments were collected and analyzed. Fisher exact test was used for categoricaldata. Univariate and multivariate logistic regressions were used to explore therelationship between clinical characteristics and patients’ severity.RESULTSIn the 61 patients, the comorbidity of type 2 diabetes, hypertension, and heartdiseases were 24.6% (15 out of 61), 37.7% (23 out of 61), and 11.5% (7 out of 61),respectively. The diabetic group was related to more invasive treatments (P =0.02) and severe status (P = 0.003). In univariate logistic regression, histories ofdiabetes (OR = 7.13, P = 0.003), hypertension (OR = 3.41, P = 0.039), and hepaticdysfunction (OR = 7.69, P = 0.002) were predictors of patients’ severity while heart disease (OR = 4.21, P = 0.083) and large lung involvement (OR = 2.70, P = 0.093)also slightly exacerbated patients’ conditions. In the multivariate analysis,diabetes (OR = 6.29, P = 0.016) and hepatic dysfunction (OR = 5.88, P = 0.018)were risk factors for severe patients. Diabetic patients showed elevated BG in61.7% of preprandial tests and 33.3% of postprandial tests, reveal