Make or break: the ribosome as a regulator of mRNA decay

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2020,（3）
• 页码范围: 195-196
• 页数: 2页
• 语种: 英文

摘要

Cells regulate α-and β-tubulin levels through a negative feedback loop which degrades tubulin mRNA upon detection of excess free tubulin protein.In a recent study in Science,Lin et al.discover a role for a novel factor,TTC5,in recognizing the N-terminal motif of tubulins as they emerge from the ribosome and in signaling co-translational mRNA decay.