Make or break: the ribosome as a regulator of mRNA decay
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摘要:
Cells regulate α-and β-tubulin levels through a negative feedback loop which degrades tubulin mRNA upon detection of excess free tubulin protein.In a recent study in Science,Lin et al.discover a role for a novel factor,TTC5,in recognizing the N-terminal motif of tubulins as they emerge from the ribosome and in signaling co-translational mRNA decay.