The in-plane magnetotransport of detwinned EuFe2As2 single crystal has been investigated.In the antiferromagnetic phase of Eu2+ spins,very different magnetoresistance results are observed upon the change of the external magnetic field direction and the current direction.This could be attributed to the tunable orientation of the Eu2+ spins under magnetic field.Electron scattering by spin fluctuation,superzone boundary effect,and cyclotron motion of charge carriers are used to interpret the observed anomalous magnetoresistance which is measured by using a current along a direction.The remarkable features of magnetoresistance suggest that itinerant electrons strongly couple with the spin configuration of Eu2+,which has a huge influence on the transport properties of EuFe2As2.