Sero-Epidemiological Study of Respiratory Syncytial Virus

• 作者: Eitaro Suzuki Mami Niida Tetsuo Nakayama
• 来源期刊: 儿科学期刊(英文)
• 学科: 数学
• 关键词: RSV SERO-EPIDEMIOLOGY Neutralizing Antibody IgG Enzyme Immunoassay
• 年，卷（期）: 2020,（3）
• 页码范围: 542-552
• 页数: 11页
• 分类号: O17

摘要

<strong>Background:</strong> <span style="font-family:Verdana;">Respiratory syncytial virus (RSV) is one of the major viruses that cause respiratory infections in all generations, not only in neonates and infants. There is a limited number of reports on serological epidemiology of RSV subgroups A and B. Neutralizing test (NT)</span><span style="font-family:""> </span><span style="font-family:Verdana;">antibody reflects protective immunity but bothersome. Sero-epidemiological study</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">should be performed using practical NT method. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> Two wild-type viruses subgroups A </span><span style="font-family:Verdana;">and B, isolated in 2013, and the Long strain was used as the challenge viruses.</span><span style="font-family:Verdana;"> NT antibody with 100% inhibition of cytopathic effect (CPE) was examined. </span><a name="_Hlk49358572"></a><span style="font-family:Verdana;">A total of 91 serum samples obtained from 0 to 12</span></span><span><span style="font-family:""> </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">years subjects without RSV</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"> infection who visited our hospital with some health problems and 121 sera obtained from healthy subjects in different age groups were used.</span></span><span></span><a name="_Hlk49358188"></a><span><span style="font-family:""> </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">Serological epidemiology of subgroups A and B was investigated in this study</span></span><span><span style="font-family:""> </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">using new NT methods.</span></span><a name="_Hlk49359976"></a><span><span style="font-family:""> <b><span style="font-family:Verdana;">Results: </span></b>