Long-term consumption of virgin coconut (Cocos nucifera) oil diet impairs learning and memory in CD1 mice

• 作者: Clement O.Nku Favour E.Abuo Olushola A.Sanya Sunday A.Bisong Sunday O.Ita Victor A.Fischer
• 来源期刊: 中草药（英文版）
• 年，卷（期）: 2020,（4）
• 所属期刊栏目: Original Articles
• 页码范围: 414-420
• 页数: 7页
• 语种: 英文

摘要

Objective: Virgin coconut oil (VCO) has been used in the management of dementia in Alzheimer's disease (AD).Therefore,this research investigated the effect of long-term consumption of VCO diet on learning and memory in CD1 mice.Methods: Thirty male CD1 mice (divided into three groups,n =10) were fed with standard rodent chow (control),5％ and 20％ VCO diets (respectively) for 28 d.The Morris Water Maze (MWM) test was used to test the effect of VCO on visuo-spatial learning and memory,while the Novel Object Recognition Test (NORT) was used to measure short-and long-term recognition memory.Results: Learning performance of mice did not differ in the MWM.During the probe trial,duration in the retention quadrant and annulus crossings were lower (P ＜ 0.05) in the 5％ and 20％ VCO diet groups compared to the control diet group,showing that VCO impaired visuo-spatial memory.During the NORT,mice showed more total approaches in the 20％ VCO diet group (P ＜ 0.05) compared to control and the 5％ VCO diet groups during the short-term memory test.During the long-term memory retention test,the total approaches were also higher in the 20％ VCO group compared to control and 5％ VCO group (P ＞0.05).The discrimination index was also lower in the 20％ VCO group compared to control and 5％ VCO diet groups indicating impaired long-term cognitive memory in mice given 20％ VCO diet.Histological examination of brains showed damage within the CA1 pyramidal cell layer of the hippocampus in the 20％ VCO diet group,in line with the behavioural observations.Conclusion: Long-term consumption of virgin coconut oil diet impairs memory in mice.