Effect of Essential Oil of Zhumeria majdae on Morphine Tolerance and Dependence in Mice

• 作者: Hamed Shafaroodi Jinous Asgarpanah Zahra Ehtemami
• 来源期刊: 中国结合医学杂志（英文版）
• 年，卷（期）: 2020,（9）
• 所属期刊栏目: Original Articles
• 页码范围: 683-687
• 页数: 5页
• 语种: 英文
• DOI: 10.1007/s11655-020-3424-9

摘要

Objective: To evaluate the effects of Zhumeria majdae essential oil (ZMEO) on morphine dependence and tolerance in mice.Methods: ZMEO (10,20,and 40 mg/kg) and clonidine (0.1 mg/kg) as the positive control were injected intraperitoneally (i.p.).The effect of ZMEO and clonidine on the dependence were evaluated by counting the number of jumps induced by naloxone (5 mg/kg) while the tolerance was evaluated by the tail-flick test.Results: ZMEO at the dose of 10 mg/kg during the development period led to a significant inhibition of morphine tolerance (P＜0.01),while it led to reduced morphine dependence with the doses of 20 and 40 mg/kg.ZMEO at two dose levels of 20 and 40 mg/kg indicated significant antinociceptive activity (P＜0.01),and significantly reduced the withdrawal signs (number of jumps) of mice (P＜0.01).Conclusions: ZMEO had significant effects on morphine tolerance and dependence.The linalool rich essential oil of Z.majdae plays a major role in the reduction of tolerance and dependence induced by morphine.