Patient with frontal-variant syndrome in early-onset Alzheimer's disease

• 作者: Han Cai Su Ning Wei Li Xia Li Shifu Xiao Lin Sun
• 来源期刊: 综合精神医学
• 年，卷（期）: 2020,（2）
• 所属期刊栏目: Case reports
• 页码范围: 114-117
• 页数: 4页
• 语种: 中文
• DOI: 10.1136/gpsych-2019-100173

摘要

The clinical manifestation of frontal-variant Alzheimer's disease (fvAD) is not typical,and it is difficult yet necessary to differentiate fvAD from frontal-variant frontal temporal dementia (fvFTD).We describe a patient with early-onset Alzheimer's disease (AD) who presented with an fvFTD-like syndrome and apolipoprotein E ε3/ε4 genotype.A brain amyloid imaging procedure,11C-Pittsburgh compound B positron emission tomography (PET),supported the final diagnosis of AD.Our present case highlights the clinical variability that characterises early-onset AD.A multimodal approach is crucial when assessing rare forms of dementia.