Postnatal renin-angiotensin system inhibition prevents renal damage from prenatal inflammation in rats

• 作者: Deng Youcai Guo Wei Han Qi Ji Yan Li Xiaohui Sun Xiongshan Wang Fangjie Yang Yao Yang Yongjian
• 来源期刊: 中医杂志（英文版）
• 年，卷（期）: 2020,（4）
• 所属期刊栏目: Research Articles
• 页码范围: 646-653
• 页数: 8页
• 语种: 英文

摘要

OBJECTIVE: To assess the protective role of benazepril,an angiotensin-converting enzyme inhibitor,in renal damage caused by prenatal inflammation.METHODS: Saline or lipopolysaccharide were administered intraperitoneally to pregnant SpragueDawley rats on gestation days 8,10,and 12.After birth,offspring received either tap water or benazepril in water between 7 and 68 weeks.Blood pressure,blood urea nitrogen,creatinine,and 24-h urine volume were measured as indices of renal function.Hematoxylin,eosin,periodic acid-Schiff,and Sirius Red staining were used to evaluate renal damage.RESULTS: Postnatal benazepril treatment ameliorated hypertension and restored normal 24-h urine volume and blood urea nitrogen and serum creatinine levels.Benazepril treatment also reduced glycoprotein accumulation and fibrosis in the glomerulus and in tubular epithelial cells and inhibited nuclear factor-kappa B activation.CONCLUSION: Together with our previous findings that postnatal inhibition of nuclear factor-kappa B activation blocks intra-renal renin-angiotensin system activation,our current data demonstrate that intra-renal activation of the renin-angiotensin system interacts with nuclear factor-kappa B activation to cause renal damage in adulthood following prenatal inflammation.