Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2020,（9）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 741-744
• 页数: 4页
• 语种: 英文
• DOI: 10.1093/jmcb/mjaa025

摘要

Dear Editor, Mammalian target of rapamycin com-plex 1 (mTORC1) serves as a central reg-ulator of cell growth and proliferation by integrating signals from growth factors,nutrients,energy status,and cellular stress (Saxton and Sabatini,2017).A small GTPase,called Ras homolog enriched in brain (Rheb),is a positive regulator of mTORC1.Like other small GTPases,the function of Rheb is dictated by its guanine nucleotide binding states:it is active in the GTP-bound form and in-active in the GDP-bound form (Aspuria and Tamanoi,2004).