CAR trafficking does matter:prospects of'Chimeric antigen receptor designed to prevent ubiquitination and downregulation showed durable antitumor efficacy'

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2020,（9）
• 所属期刊栏目: Research Advance
• 页码范围: 745-746
• 页数: 2页
• 语种: 英文
• DOI: 10.1093/jmcb/mjaa045

摘要

Chimeric antigen receptor (CAR) is a synthetic antigen receptor containing a specific antigen-recognition ectodomain to make T cells selectively attack cancer cells,a hinge-transmembrane region to confer stable surface expression,and one or more intracellular signaling domains to regulate T-cell activation.CAR T-cell ther-apy has produced unprecedented clinical outcomes for treating cancers,particularly B-cell malignancies.