Clear Cell Sarcoma (CCS) is a rare soft tissue sarcoma that corresponds <span style="font-family:Verdana;">to </span><span style="font-family:Verdana;">a less than 1% of all sarcomas</span><span style="font-family:Verdana;"> and</span><span style="font-family:Verdana;"> is a high degree neoplasm with propensity to disseminate to regional lymph nodes. Regional lymphadenectomies have </span><span style="font-family:Verdana;">a </span><span style="font-family:Verdana;">controversial impact on sarcomas treatment and survival, even though those patients have higher local recurrence and lower survival. So, sentinel lymph node biopsy must be one option for better regional staging to STS with higher propensity to lymph node commitment. The authors demonstrate two cases of CCS submitted to surgery through compartmental resection associated </span><span style="font-family:Verdana;">with</span><span style="font-family:Verdana;"> the sentinel lymph node biopsy. A literature review about soft tissue sarcoma and lymph node sentinel biopsy </span><span style="font-family:Verdana;">is</span><span style="font-family:Verdana;"> show</span><span style="font-family:Verdana;">n </span><span style="font-family:Verdana;">as an initial experience of two cases.</span>