Progress in human liver organoids

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2020,（8）
• 所属期刊栏目: Reviews
• 页码范围: 607-617
• 页数: 11页
• 语种: 英文
• DOI: 10.1093/jmcb/mjaa013

摘要

Understanding the development, regeneration, and disorders of the liver is the major goal in liver biology. Current mechanistic knowledge of human livers has been largely derived from mouse models and cell lines, which fall short in recapitulating the features of human liver cells or the structures and functions of human livers. Organoids as an in vitro system hold the promise to generate organ-like tissues in a dish. Recent advances in human liver organoids also facilitate the understanding of the biology and diseases in this complex organ. Here we review the progress in human liver organoids, mainly focusing on the methods to generate liver organoids, their applications, and possible future directions.