Multi-scale mechanotransduction of the poroelastic signals from osteon to osteocyte in bone tissue

• 作者: Chaoxin Li Kuijun Chen Meizhen Zhang Weilun Yu Weiyi Chen Xiaogang Wu Yanqin Wang Yixian Qin Yuqin Sun
• 来源期刊: 力学学报（英文版）
• 年，卷（期）: 2020,（4）
• 所属期刊栏目: BIOMECHANICS
• 页码范围: 964-980
• 页数: 17页
• 语种: 英文

摘要

In order to quantify the poroelastic mechanical signals conduction and evaluate the biomechanical effectiveness of functional units (osteocyte processes,canaliculi and lacuna) in lacunar-canalicular system (LCS),a multiscale poroelastic finite element model was established by using the Comsol Multiphysics software.The poroelastic mechanical signals (pore pressure,fluid velocity,von-Mises stress,strain) were analyzed inside the osteon-osteocyte system.The effects of osteocyte (OCY)'s shape (ellipse and circle),long axis directions (horizontal and vertical) and mechanical properties (Elastic modulus and permeability) on its poroelastic responses were examined.It is found that the OCY processes is the best mechanosensor compared with the OCY body,lacunae and canaliculi.The mechanotransduction ability of the elliptic shaped OCY is stronger than that of circular shaped.The pore pressure and flow velocity around OCYs increase as the elastic modulus and permeability of OCY increase.The established model can be used for studying the mechanism of bone mechanotransduction at the multiscale level.