Acute changes in ganglion cell layer thickness in ischemic optic neuropathy compared to optic neuritis using optical coherence tomography

• 作者: Peter W.MacIntosh S.Vijay Kumar V.R.Saravanan Virna M.Shah
• 来源期刊: 国际眼科杂志:英文版
• 学科: 工学
• 关键词: OPTIC NEURITIS non-arteritic ischemic OPTIC NEUROPATHY optical COHERENCE tomography GANGLION cell layer
• 年，卷（期）: 2020,（1）
• 页码范围: 120-123
• 页数: 4页
• 分类号: TU5

摘要

AIM:To elucidate the changes of different ganglion cell layer(GCL)thinning patterns between the optic neuritis(ON)and non-arteritic anterior ischemic optic neuropathy(NAION).METHODS:A prospective,observational study was conducted to evaluate the timing of GCL changes between acute ON and NAION using optical coherence tomography.RESULTS:Thinning on optical coherence tomography in the NAION group occurs as early as 11 d after symptomatic onset of vision loss and follows an altitudinal pattern.The mean superior-inferior GCL thickness difference in the NAION cohort was clinically significant at 5.7μm in the NAION cohort compared to controls of 0.8μm(P=0.032),but not significant in the ON group compared to controls with both groups measuring 1.1μm.Global thinning was significant for the ON group compared to controls at 7.2μm(P=0.011)but not the NAION group compared to controls at 1.35μm.CONCLUSION:These findings suggest that future treatments for NAION should be given early,and possibly before 11 d in order to prevent GCL and irreversible vision loss.