Host-pathogen interaction after infection of Galleria mellonella with the filamentous fungus Beauveria bassiana

• 作者: Iwona Wojda Lidiia Vertyporokh Monika Hu(l)as-Stasiak
• 来源期刊: 中国昆虫科学（英文版）
• 年，卷（期）: 2020,（5）
• 所属期刊栏目: Original articles
• 页码范围: 1079-1089
• 页数: 11页
• 语种: 英文
• DOI: 10.1111/1744-7917.12706

摘要

The filamentous fungus Beauveria bassiana is a natural pathogen of the greater wax moth Galleria mellonella.Infection with this fungus triggered systemic immune response in G.mellonella;nevertheless,the infection was lethal if spores entered the insect hemocel.We observed melanin deposition in the insect cuticle and walls of air bags,while the invading fungus interrupted tissue continuity.We have shown colonization of muscles,air bags,and finally colonization and complete destruction of the fat body—the main organ responsible for the synthesis of defense molecules in response to infection.This destruction was probably not caused by simple fungal growth,because the fat body was not destroyed during colonization with a human opportunistic pathogen Candida albicans.This may mean that the infecting fungus is able to destroy actively the insect's fat body as part of its virulence mechanism.Finally,we were unable to reduce the extremely high virulence of B.bassiana against G.mellonella by priming of larvae with thermally inactivated fungal spores.