Galectin 3 Level in Patients with Acute Coronary Syndrome and its Relation to Severity of Coronary Artery Disease

• 作者: Aly Nasr Aly Mashal Ghada Mahmoud Soltan Niveen Ibrahim Samy
• 来源期刊: 心血管病(英文)
• 学科: 医学
• 关键词: ACS ATHEROSCLEROSIS Galectin 3 PCI Gensini Score
• 年，卷（期）: 2020,（12）
• 页码范围: 784-795
• 页数: 12页
• 分类号: R54

摘要

<strong>Background:</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"> Acute coronary syndrome (ACS) is a very common cause</span><b><span style="font-family:Verdana;"> </span></b><span style="font-family:Verdana;">of hospitalizations worldwide each year. Despite Troponin is considered the gold standard in diagnosis of ACS</span></span><span style="font-family:Verdana;">.</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> Several molecules have been investigated to identify predictive biomarkers of diagnosis. Among these, Galectin-3 has emerged as a promising diagnostic biomarker of (ACS). We aimed to evaluate galectin-3 levels in patients with acute coronary syndrome (ACS) and its relation to severity of coronary artery disease. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">Seventy two patients with ACS who underwent primary</span><b></b><span style="font-family:Verdana;">percutaneous coronary intervention (PCI) and 20 age-matched healthy controls were enrolled in our study .The severity of coronary artery disease and the burden of atherosclerosis was assessed with Gensini score and with the number of affected vessels. Galectin-3 levels were measured on admission by using ELISA with a commercially kit. </span><b><span style="font-family:Verdana;">Result: </span></b><span style="font-family:Verdana;">The mean age of the observational case control study was 55.9 ±</span><b><span style="font-family:Verdana;"> </span></b><span style="font-family:Verdana;">11.9 and 68 patients (73.9%) of the study were male. Median galectin-3 levels were significantly higher in ACS patients (20.25 ng/mL [11.9 - 39.0] vs. 8.9 ng/mL [4.6 - 24.0], P = 0.001). Patients were classified into three groups according to the number of involved vessels. Median galectin-3 levels were also significantly differen</span></span><span style="font-family:Verdana;">t</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> among gr