Delivery strategies for macromolecular drugs in cancer therapy

• 作者: Chen Jiang Qin Guo
• 来源期刊: 药学学报（英文版）
• 年，卷（期）: 2020,（6）
• 所属期刊栏目: Reviews
• 页码范围: 979-986
• 页数: 8页
• 语种: 英文

摘要

With the development of biotherapy,biomacromolecular drugs have gained tremendous attention recently,especially in drug development field due to the sophisticated functions in vivo.Over the past few years,a motley variety of drug delivery strategies have been developed for biomacromolecular drugs to overcome the difficulties in the druggability,e.g.,the instability and easily restricted by physiologic barriers.The application of novel delivery systems to deliver biomacromolecular drugs can usually prolong the half-life,increase the bioavailability,or improve patient compliance,which greatly improves the efficacy and potentiality for clinical use of biomacromolecular drugs.In this review,recent studies regarding the drug delivery strategies for macromolecular drugs in cancer therapy are summarized,mainly drawing on the development over the last five years.