Correlation between Vulvar Symptoms Stratification and Vulvar Cancer Detection: Prospective Cohort Observational Study

• 作者: Mervat A. Elsersy
• 来源期刊: 妇产科期刊(英文)
• 学科: 医学
• 关键词: Cancer VULVA Soreness LESION BLEEDING
• 年，卷（期）: 2020,（7）
• 页码范围: 866-872
• 页数: 7页
• 分类号: R73

摘要

<strong>Background:</strong> <span style="font-family:""><span style="font-family:Verdana;">The incidence of cancer vulva is increasing. 50% of cases are occurring at younger age especially the type related to Human Papilloma Virus infection. Cancer vulva can be prevented. Awareness of cancer vulva is deficient among women and healthcare providers. In this study we looked for a correlation between the most significant vulval symptoms to be associated with cancer vulva in order to educate women and to provide guidance for the health care providers. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> 569 women were enrolled in this observational cohort study. The patients were stratified according to their symptoms </span><span style="font-family:Verdana;">into 5 groups. Biopsy from the vulva, unless the lesion is obviously benign.</span> <b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> Vulvar lesion, as a symptom (mass-ulcer), was significantly associat</span><span style="font-family:Verdana;">ed with detection of vulvar cancer (</span><i><span style="font-family:Verdana;">P</span></i><span> </span></span><span style="font-family:""><span style="font-family:Verdana;">≤ </span><span><span style="font-family:Verdana;">0.001). 100% of those women presented </span><span style="font-family:Verdana;">with vulvar lesions (mass or ulcer) had cancer. Positive predictive value (PPV)</span><span style="font-family:Verdana;"> of vulvar lesion alone was 1.25% but the probability of detection of a cancer dramatically increased when the lesion was accompanied with bleeding 35.2% or pain 26.9% respectively. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> Presenting symptoms other than a lesion in the vulva as for example, soreness, irritation or bleeding was rarely associated with detection of cancer.</span></span></span>