Current Review of Systemic Juvenile Idiopathic Arthritis: What Do Paediatricians Need to Know?

• 作者: Asma R. Albaker
• 来源期刊: 儿科学期刊(英文)
• 学科: 医学
• 关键词: Juvenile Idiopathic Arthritis Systemic Juvenile Idiopathic Arthritis AUTOINFLAMMATORY ARTHRITIS BIOLOGICS
• 年，卷（期）: 2020,（4）
• 页码范围: 769-801
• 页数: 33页
• 分类号: R59

摘要

Systemic </span><span><span style="font-family:Verdana;">juvenile idiopathic arthritis is classified as an autoimmune entity and a subtype of juvenile idiopathic arthritis, although it has many features of autoinflammatory-type of diseases. This review article will elaborate on the disease’s pathogenesis and its proposed relation to autoinflammatory diseases including defective innate immunity and phagocytosis response leading </span><span style="font-family:Verdana;">excessive</span><span style="font-family:Verdana;"> cytokine release. It also explains the disease’s epidemiology, clinical phenotype, diagnostic challenges, complications </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> current advancements in the treatment of systemic juvenile idiopathic arthritis, such as IL-1 and IL-6 antagonists </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> their impact on the disease trajectory. Care of patients with systemic juvenile idiopathic arthritis requires a comprehensive multidisciplinary team to optimize the care and avoid complications of the disease itself such as growth impairment, macrophage activation syndrome </span><span style="font-family:Verdana;">or</span><span style="font-family:Verdana;"> the complications of immunosuppressant and immun</span></span><span style="font-family:Verdana;">omodulatory treatments.