Long-lasting microbial larvicides for controlling insecticide resistant and outdoor transmitting vectors:a cost-effective supplement for malaria interventions

• 作者: Guofa Zhou Eugenia Lo Andrew K.Githeko Yaw A.Afrane Guiyun Yan
• 来源期刊: 贫困所致传染病（英文）
• 年，卷（期）: 2020,（6）
• 所属期刊栏目: OPINION
• 页码范围: 83-90
• 页数: 8页
• 语种: 英文

摘要

The issues of pyrethroid resistance and outdoor malaria parasite transmission have prompted the WHO to call for the development and adoption of viable alternative vector control methods.Larval source management is one of the core malaria vector interventions recommended by the Ministry of Health in many African countries,but it is rarely implemented due to concerns on its cost-effectiveness.New long-lasting microbial larvicide can be a promising cost-effective supplement to current vector control and elimination methods because microbial larvicide uses killing mechanisms different from pyrethroids and other chemical insecticides.It has been shown to be effective in reducing the overall vector abundance and thus both indoor and outdoor transmission.In our opinion,the long-lasting formu-lation can potentially reduce the cost of larvicide field application,and should be evaluated for its cost-effectiveness,resistance development,and impact on non-target organisms when integrating with other malaria vector control measures.In this opinion,we highlight that long-lasting microbial larvicide can be a potential cost-effective product that complements current front-line long-lasting insecticidal nets(LLINs)and indoor residual spraying(IRS)programs for malaria control and elimination.Microbiallarviciding targets immature mosquitoes,reduces both indoor and out-door transmission and is not affected by vector resistance to synthetic insecticides.This control method is a shift from the conventional LLINs and IRS programs that mainly target indoor-biting and resting adult mosquitoes.