Organoid-based chemical approach to dissect the mechanism controlling cellular dynamics

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2020,（8）
• 所属期刊栏目: Highlight
• 页码范围: 666-667
• 页数: 2页
• 语种: 英文
• DOI: 10.1093/jmcb/mjz100

摘要

Organoids are self-organizing in vitro three-dimensional (3D) tissue cultures containing multiple types of cells. Com-pared to traditional two-dimensional (2D)cell culture systems, 3D organoids bet-ter replicate the architecture, complex-ity, and physiology of an organ (Figure 1). In addition, 3D organoids are eas-ier to scale up and more cost-efficient when compared to animal models. In the past decade, organoid technology has risen rapidly and become increas-ingly more prevalent among researchers.