Serum Levels of Reproductive Hormones and Their Relationship with Age in Men with Benign Prostatic Hyperplasia in Benin City, Edo State

• 作者: Babatunde Ishola Gabriel Adejumo Efosa Bolaji Odigie Ifeoma Gloria Unachukwu Ojo Moses Oke Oladimeji Nasiru Abdulrahman Omolei Lilian Williams Oyarazi Margaret Adebowale Simon Uzor Uchechukwu Dimkpa
• 来源期刊: 健康(英文)
• 学科: 医学
• 关键词: HORMONES Age MEN PROSTATE HYPERPLASIA
• 年，卷（期）: jkyw_2020,（9）
• 页码范围: 1121-1131
• 页数: 11页
• 分类号: R69

摘要

<strong>Background: </strong>Benign Prostatic Hyperplasia (BPH) is a common condition which occurs as men get older. <strong>Aim:</strong> We aimed at investigating the reproductive hormone profile of men with BPH and the relationship of these hormones with age. <strong>Methods:</strong> Twenty-nine men of age > 40 years were screened for prostate symptoms. The prostate examination included digital rectal examination and measurement of serum prostate-specific antigen levels. Demographic and clinical characteristics of subjects were obtained using a structured questionnaire. The serum levels of Testosterone (Te), Luteinizing hormone (LH), Follicle stimulating hormone (FSH) and Prolactin (PRL) were measured using ELISA method. <strong>Results:</strong> Our study indicated that age and levels of prostate specific antigen (PSA), LH and FSH were significantly (p < 0.05) higher in men with BPH compared with healthy controls. In contrast, the control group indicated significantly (p < 0.05) higher Te level compared with the BPH group. In patients with BPH, age was significantly (p < 0.05) correlated with the hypothalamic-pituitary-testicular axis hormones (LH, FSH and PRL), but not with the sex hormone, and testosterone. Majority (62.1%) of the patients with BPH indicated they had poor libido, while none of them indicated regular sexual activity with their spouses. <strong>Conclusion:</strong> This study suggests that the rise in serum levels of the hypothalamic-pituitary-testicular axis hormones in BPH patients as demonstrated by the present findings may be age-related since testicular dysfunction in aging men is associated with the decrease in androgen production which may stimulate an increased production of gonadotropins by negative feedback.