SIRT5 is important for bacterial infection by regulating insulin secretion and glucose homeostasis

• 作者: Cuiping Zhang Ke Wang Zuojian Hu Lujie Yang Bin Wei Shan Li Xue Qin Pengyuan Yang Hongxiu Yu
• 来源期刊: 蛋白质与细胞
• 年，卷（期）: 2020,（11）
• 所属期刊栏目: LETTERS
• 页码范围: 846-851
• 页数: 6页
• 语种: 英文

摘要

Dear Editor, Recent studies indicate that cellular metabolism plays a key role in supporting immune cell development,mainte-nance and function(Norata et al.,2015).For example,sensing of microbial ligands by macrophages triggers increased glucose metabolism,which delivers energy to support antimicrobial inflammation and the production of cytokines.This effect further enhances the generation of mitochondrial reactive oxygen species(ROS)to fight infec-tions.Tucey et al.show that maintaining host glucose homeostasis is important to prevent life-threatening fungal infection(Tucey et al.,2018).This phenomenon emerges as a bedrock of the emerging concept of how metabolism and immunity are integrated based on bioenergy requirements.