Gestational Trophoblastic Neoplasia: Clinical and Therapeutic Profile in Madagascar

• 作者: Florine Rafaramino Malala Razakanaivo Norosoa Randriamaroson Ny Ony Andrianandrasana Zo Ambinintsoa Solofonirina
• 来源期刊: 妇产科期刊(英文)
• 学科: 医学
• 关键词: CHORIOCARCINOMA Gestational Trophoblastic Disease Gestational Trophoblastic Neoplasia Madagascar
• 年，卷（期）: fckqkyw_2020,（7）
• 页码范围: 946-956
• 页数: 11页
• 分类号: R73

摘要

Gestational trophoblastic disease (GTD) develops from abnormal cellular proliferatio<span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">n of trophoblasts following fertilization. This includes complete and </span><span style="font-family:Verdana;">partial hydatidiform mole (HM) and gestational trophoblastic neoplasia (GTN).</span><span style="font-family:Verdana;"> The </span><span style="font-family:Verdana;">aim of this study was to report the epidemiological, clinical and thera</span><span style="font-family:Verdana;">peutic profile of gestational trophoblastic neoplasia (GTN) over period of ten years in the department of Oncology Radiotherapy at the University Hospital </span><span style="font-family:Verdana;">Joseph Ravoahangy Andrianavalona (HJRA) Antananarivo </span><span style="font-family:Verdana;">Madagascar. Medical records of women diagnosed with GTD in the department of Oncology Radiotherapy at HJRA from January 1st, 2007 to September 2017 were retrospectively reviewed. Only patients with the FIGO diagnosis GTN were in</span><span style="font-family:Verdana;">cluded, while those with the histological diagnosis of hydatidiform mole (HM)</span><span style="font-family:Verdana;">, also sometimes classified as GTD, were not included in this study. Also excluded</span><span style="font-family:Verdana;"> were all cases with incomplete or missing data. Twenty four pati</span><span style="font-family:Verdana;">ents were included. Median age of patients at the time of diagnosis was 37 years (range 18 - 60). Most patients developed GTN following molar pregnancy (75%), had disease duration from antecedent pregnancy of less than 6 months </span><span style="font-family:Verdana;">(58.20%), and had the pre-treatment hCG level more than 10,000 IU/L (58.27%).</span><span style="font-family:Verdana;"> At diagnosis, 14 patients (58.33%) had localized disease (M0). Most common metastatic sites at initial diagnosis were the liver and brain (20.83%). After a median follow-up from initial diagn