Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy: opportunities, challenges, and future development

• 作者: Dongyang Zhao Gang Wang Jin Sun Linlin Cao Qikun Jiang Yang Wang Yixin Sun Zhonggui He
• 来源期刊: 药学学报（英文版）
• 年，卷（期）: 2020,（8）
• 所属期刊栏目: Reviews
• 页码范围: 1382-1396
• 页数: 15页
• 语种: 英文

摘要

Hypoxia,a salient feature of most solid tumors,confers invasiveness and resistance to the tumor cells.Oxygen-consumption photodynamic therapy (PDT) suffers from the undesirable impediment of local hypoxia in tumors.Moreover,PDT could further worsen hypoxia.Therefore,developing effective strategies for manipulating hypoxia and improving the effectiveness of PDT has been a focus on antitumor treatment.In this review,the mechanism and relationship of tumor hypoxia and PDT are discussed.Moreover,we highlight recent trends in the field of nanomedicines to modulate hypoxia for enhancing PDT,such as oxygen supply systems,down-regulation of oxygen consumption and hypoxia utilization.Finally,the opportunities and challenges are put forward to facilitate the development and clinical transformation of PDT.