Possible mechanisms underlying treatment of Alzheimer's disease with Traditional Chinese Medicine: active components, potential targets and synthetic pathways of Bulao Elixir

• 作者: Cheng Fafeng Du Xin Hao Gaoting Ji Wenting Liu Shuling Ma Chongyang Ren Beida Wan Yuxiang Wang Qingguo Wang Xueqian Xiong Yiliang Zhang Shuang
• 来源期刊: 中医杂志（英文版）
• 年，卷（期）: 2020,（3）
• 所属期刊栏目: Research Articles
• 页码范围: 484-496
• 页数: 13页
• 语种: 英文

摘要

OBJECTIVE: To elucidate the mechanisms underlying the treatment of Alzheimer's disease (AD) with Traditional Chinese Medicine (TCM),by examining the active components,potential targets and synthetic pathways of Bulao Elixir (BLE).METHODS: The Absorption,Distribution,Metabolism,Excretion (ADME)/Toxicology (T) calculation was used to screen the active components of Bulao Elixir.Based on the TCM Systems Pharmacology Analysis Platform (TCMSP database) and a text mining tool (GoPubMed database),we predicted and screened the active components of Bulao Elixir and its therapeutic targets for AD.Using the Database for Annotation,Visualization and Integrated Discovery (DAVID),we obtained the targets for AD.Cytoscape software was used to establish a network map of the active component-target and target-pathway of Bulao Elixir.Gene function,related biological processes and signaling pathways were analyzed using the DAVID database.RESULTS: Twelve active components were selected from 196 components of Bulao Elixir.Among 2209 targets,102 effective targets were selected,and 30 important targets were identified via matching with the disease targets.After further analysis,14 core targets were identified.Enrichment analysis re vealed that most of these important targets wereinvolved in multiple biological processes,including apoptosis,inflammatory reactions,and cell regulation cycles.The synthetic pathways for AD treatment were identified after analyzing and confirming the relevant pathways,providing potentially useful information for diagnosis and treatment methods for AD.CONCLUSION: The current study elucidated the potential treatment mechanisms of Bulao Elixir in AD using network pharmacology,providing a foundation for further clarification of its treatment targets.