Improving control effects of absence seizures using single-pulse alternately resetting stimulation (SARS) of corticothalamic circuit

• 作者: Denggui FAN Qingyun WANG Yanhong ZHENG Zecheng YANG
• 来源期刊: 应用数学和力学（英文版）
• 学科: 数学
• 年，卷（期）: 2020,（9）
• 页码范围: 1287-1302
• 页数: 16页
• 分类号: O175|O322
• 语种: 英文

摘要

Presently,we develop a simplified corticothalamic (SCT) model and propose a single-pulse alternately resetting stimulation (SARS) with sequentially applying anodic (A,"+") or cathodic (C,"-") phase pulses to the thalamic reticular (RE) nuclei,thalamus-cortex (TC) relay nuclei,and cortical excitatory (EX) neurons,respectively.Abatement effects of ACC-SARS of RE,TC,and EX for the 2Hz-4Hz spike and wave discharges (SWD) of absence seizures are then concerned.The m:n on-off ACC-SARS protocol is shown to effectively reduce the SWD with the least current consumption.In particular,when its frequency is out of the 2 Hz-4 Hz SWD dominant rhythm,the desired seizure abatements can be obtained,which can be further improved by our proposed directional steering (DS) stimulation.The dynamical explanations for the SARS induced seizure abatements are lastly given by calculating the averaged mean firing rate (AMFR)of neurons and triggering averaged mean firing rates (TAMFRs) of 2 Hz-4 Hz SWD.