A Comprehensive Review on Human Aichi Virus

• 来源期刊: 中国病毒学
• 年，卷（期）: 2020,（5）
• 所属期刊栏目: REVIEW
• 页码范围: 501-516
• 页数: 16页
• 语种: 英文

摘要

Although norovirus,rotavirus,adenovirus and Astrovirus are considered the most important viral agents transmitted by food and water,in recent years other viruses,such as Aichi virus(AiV),have emerged as responsible for gastroenteritis outbreaks associated with different foods.AiV belongs to the genus Kobuvirus of the family Picornaviridae.It is a virus with icosahedral morphology that presents a single stranded RNA genome with positive sense(8280 nucleotides)and a poly(A)chain.AiV was first detected from clinical samples and in recent years has been involved in acute gastroenteritis outbreaks from different world regions.Furthermore,several studies conducted in Japan,Germany,France,Tunisia and Spain showed a high prevalence of AiV antibodies in adults(between 80％ and 99％),which is indicative of a large exposure to this virus.The aim of this review is to bring together all the discovered information about the emerging pathogen human Aichi virus(AiV),discussing the possibles routes of transmission,new detection techniques and future research.Although AiV is responsible for a low percentage of gastroenteritis outbreaks,the high seroprevalence shown by human populations indicates an evident role as an enteric agent.The low percentage of AiV detection could be explained by the fact that the pathogen is more associated to subclinical infections.Further studies will be needed to clarify the real impact of AiV in human health and its importance as a causative gastroenteritis agent worldwide.