Comparative genomics reveal shared genomic changes in syngnathid fishes and signatures of genetic convergence with placental mammals

• 作者: Byrappa Venkatesh Feng-Ming Han Geng Qin He Dai Hui-Xian Zhang Jian-Ping Yin Liang-Min Huang Qiang Lin Vydianathan Ravi Xin Wang Yan-Hong Zhang Yu-Hong Liu
• 来源期刊: 国家科学评论（英文版）
• 关键词: Manado pipefish whole-genome sequencing transposable elements placenta-like structure convergent evolution
• 年，卷（期）: 2020,（6）
• 页码范围: 964-977
• 页数: 14页
• 语种: 英文
• DOI: 10.1093/nsr/nwaa002

摘要

Syngnathids (seahorses,pipefishes and seadragons) exhibit an array of morphological innovations including loss of pelvic fins,a toothless tubular mouth and male pregnancy.They comprise two subfamilies:Syngnathinae and Nerophinae.Genomes of three Syngnathinae members have been analyzed previously.In this study,we have sequenced the genome ofa Nerophinae member,the Manado pipefish (Microphis manadensis),which has a semi-enclosed brood pouch.Comparative genomic analysis revealed that the molecular evolutionary rate of the four syngnathids is higher than that of other teleosts.The loss of all but one P/Q-rich SCPP gene in the syngnathids suggests a role for the lost genes in dentin and enameloid formation in teleosts.Genome-wide comparison identified a set of 118 genes with parallel identical amino acid substitutions in syngnathids and placental mammals.Association of some of these genes with placental and embryonic development in mammals suggests a role for them in syngnathid pregnancy.