Research progress on the source,production,and anti-cancer mechanisms of paclitaxel

• 来源期刊: 中国天然药物
• 年，卷（期）: 2020,（12）
• 所属期刊栏目: Reviews
• 页码范围: 890-897
• 页数: 8页
• 分类号: R965
• 语种: 英文
• DOI: 10.1016/S1875-5364(20)60032-2

摘要

Paclitaxel,a tetracyclic diterpenoid compounds,was firstly isolated from the bark of the Pacific yew trees.Currently,as a low toxicity,high efficiency,and broad-spectrum natural anti-cancer drug,paclitaxel has been widely used against ovarian cancer,breast cancer,uterine cancer,and other cancers.As the matter of fact,natural paclitaxel from Taxus species has been proved to be en-vironmentally unsustainable and economically unfeasible.For this reason,researchers from all over the world are devoted to searching for new ways of obtaining paclitaxel.At present,other methods,including artificial cultivation of Taxus plants,microbial fermentation,chemical synthesis,tissue and cell culture have been sought and developed subsequently.Meanwhile,the biosynthesis of paclitaxel is also an extremely attractive method.Unlike other anti-cancer drugs,paclitaxel has its unique anti-cancer mechanisms.Here,the source,production,and anti-cancer mechanisms of paclitaxel were summarized and reviewed,which can provide theoretical basis and refer-ence for further research on the production,anti-cancer mechanisms and utilization of paclitaxel.