The influence of porosity on tablet subdivision

• 作者: Maíra T.Teixeira Livia L.Sa-Barreto Izabel C.Silva Tais Gratieri Guilherme M.Gelfuso Ricardo N.Marreto Mariana Landin Marcilio Cunha-Filho
• 来源期刊: 颗粒学报（英文版）
• 年，卷（期）: 2020,（6）
• 页码范围: 192-196
• 页数: 5页
• 语种: 英文

摘要

A tablet microstructure,especially the porosity,is a crucial parameter that influences the mechanical properties.Herein,tablet subdivisions were studied as a function of tablet porosity.The tablets were man-ufactured in the presence of different diluents,namely microcrystalline cellulose,Ludipress?,or lactose monohydrate.Furthermore,the addition of Camphor was investigated,which was thereafter sublimated with a view of obtaining tablets having varying degrees of porosity.Microstructural assays were corre-lated to the subdivision performance.The increase in porosity reduced the hardness and increased the tablet friability,adversely impacting the subdivision.For all the excipients,an increase in relative poros-ity＞90％represented the threshold level from which an inadequate subdivision occurred.The increase in tablet porosity led to a reduction in mechanical resistance,which,combined with a heterogeneous and discontinuous distribution of pores within the matrix,resulted in poor subdivision results.Controlling tablet porosity is an important consideration when designing tablets having a subdivision purpose.