Anti-cancer Effect of 20(S)-Ginsenoside-Rh2 on Oral Squamous Cell Carcinoma Cells via the Decrease in ROS and Downregulation of MMP-2 and VEGF

• 作者: CAO Rui CHENG Jing Yang GAO Shu Ting HUANG Chun Juan LI Bo LI Rui Ping LI Zhi Ge LIU Bin NING Jing ZHANG Bao Ping
• 来源期刊: 生物医学与环境科学（英文版）
• 年，卷（期）: 2020,（9）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 713-717,中插8-中插9
• 页数: 1页
• 语种: 英文
• DOI: 10.3967/bes2020.093

摘要

Squamous cell carcinoma (SCC) is the most common in oral and maxillofacial regions and occupy more than 90％ of the malignant lesions in the oral cavity[1]. The complex anatomy of the head and neck region gives rise to intricate patterns of local invasion and regional spread, which makes primary tumors more difficult to eradicate. Surgical resection combined with chemotherapy using cytotoxic drugs or radiation therapy are routine means for the treatment of SCC. However, drug resistance, severe side effects, and high recurrence rate markedly limit the effectiveness of clinical treatments. Consequently, the search for novel anti-cancer strategies with low toxicity has acquired the interest of many researchers.