Isochlorogenic acid(ICGA):natural medicine with potentials in pharmaceutical developments

• 来源期刊: 中国天然药物
• 年，卷（期）: 2020,（11）
• 所属期刊栏目: Review
• 页码范围: 860-871
• 页数: 12页
• 分类号: R965
• 语种: 英文
• DOI: 10.1016/S1875-5364(20)60029-2

摘要

Natural products have attracted a great deal of attention as significant resources in traditional Chinese medicine(TCM)and in chemical medicine,as well as in cosmetic ingredients,nutraceuticals and food products.Isochlorogenic acid(ICGA),which has medicinal value,has been discovered in various plants.As a widespread natural medicine,ICGA should be the subject of further re-search and development.However,there have been no systematic analyses of ICGA.According to our investigation,ICGA was ini-tially isolated from green coffee extracts by Barnes et al.in 1950.To date,it has been discovered in a variety of tea,vegetables,medi-cinal diet and TCM materials.ICGA is used as a chemical marker for the quality control of these TCM materials.The metabolic pro-cess of ICGA has been studied in detail,conforming to be linear dynamics.Thus,the clear pharmacokinetics of ICGA offers a solid foundation for its research and development.ICGA has multiple biological and pharmacological effects,and studies have mainly fo-cused on its antioxidant,anti-inflammatory,antimicrobial,hypoglycemic,neuroprotective,and cardiovascular protective effects,and hepatoprotective properties.The mechanisms underlying these effects are summarized in this review to provide scientific support and inspiration for the future research and development of ICGA and ICGA-rich natural products.