Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects

• 作者: Chen Chen Chuanchuan He Guangya Xiang Minsi Li Muhammad Sarfraz Muhammad Waseem Khan Pengxuan Zhao Robert J.Lee Ruicong Yan Tan Yang Ting Fan Xiang Ma Xiaojuan Zhang Yan Chen Yao Lu
• 来源期刊: 药学学报（英文版）
• 年，卷（期）: 2020,（6）
• 所属期刊栏目: Original articles
• 页码范围: 1106-1121
• 页数: 16页
• 语种: 英文

摘要

Platinum-based chemotherapy is used for non-small cell lung cancer (NSCLC).However,it has side effects and minimum efficacy against lung cancer metastasis.In this study,platinum-curcumin complexes were loaded into pH and redox dual-responsive nanoparticles (denoted as Pt-CUR@PSPPN) to facilitate intracellular release and synergistic anti-cancer effects.Pt-CUR@PSPPN was prepared by a nano-precipitation method and had a diameter of ～ 100 nm.The nanoparticles showed increased anticancer effects both in vivo and in vitro.In addition,Pt-CUR@PSPPN blocked PI3K/AKT signal transduction pathway and inhibited MMP2 and VEGFR2,resulting in enhanced anti-metastatic activity.Furthermore,reduced side effects were also observed.In conclusion,Pt-CUR@PSPPN provided a novel and attractive therapeutic strategy for NSCLC.