The accompanying comment by Dr.Rao, suggests that there is an omission of citation of 12 previous publications in our Wang et al.paper.1 We disagree with the suggestion for the following reasons.
We believe that the 12 publications cited by Dr.Rao do not have sufficient relevance to the Wang et al.paper.1 The past decades have witnessed an explosive growth in our understanding of the pathogenesis of Alzheimer's disease (AD), which is a very complicated process.The Wang et al.paper specifically reports a distinct and novel mechanism of GV-971 in the treatment of AD,from the angle of gut microbiota and associated neuroinflammation.