Wearable skin-like optoelectronic systems with suppression of motion artifacts for cuff-less continuous blood pressure monitor

• 来源期刊: 国家科学评论（英文版）
• 关键词: skin-like devices optoelectronics blood pressure monitor optical measurement
• 年，卷（期）: 2020,（5）
• 页码范围: 849-862
• 页数: 14页
• 语种: 英文
• DOI: 10.1093/nsr/nwaa022

摘要

According to the statistics of the World Health Organization,an estimated 17.9 million people die from cardiovascular diseases each year,representing 319％ of all global deaths.Continuous non-invasive arterial pressure (CNAP) is essential for the management of cardiovascular diseases.However,it is difficult to achieve long-term CNAP monitoring with the daily use of current devices due to irritation of the skin as well as the lack ofmotion artifacts suppression.Here,we report a high-performance skin-like optoelectronic system integrated with ultra-thin flexible circuits to monitor CNAP.We introduce a theoretical model via the virtual work principle for predicting the precise blood pressure and suppressing motion artifacts,and propose optical difference in the frequency domain for stable optical measurements in terms of skin-like devices.We compare the results with the blood pressure acquired by invasive (intra-arterial) blood pressure monitoring for ＞ 1500 min in total on 44 subjects in an intensive care unit.The maximum absolute errors of diastolic and systolic blood pressure were ±-7/±-10 mm Hg,respectively,in immobilized,and ±-10/±14 mm Hg,respectively,in walking scenarios.These strategies provide advanced blood pressure monitoring techniques,which would directly address an unmet clinical need or daily use for a highly vulnerable population.