Efficient drug and gene delivery to liver fibrosis:rationale, recent advances, and perspectives

• 作者: Ala Amiri Hadi Valizadeh Parvin Zakeri-Milani Salar Hemmati Seyed Hossein Kiaie Somayeh Mahdinloo
• 来源期刊: 药学学报（英文版）
• 年，卷（期）: 2020,（7）
• 所属期刊栏目: Reviews
• 页码范围: 1279-1293
• 页数: 15页
• 语种: 英文

摘要

Liver fibrosis results from chronic damages together with an accumulation of extracellular matrix,and no specific medical therapy is approved for that until now.Due to liver metabolic capacity for drugs,the fragility of drugs,and the presence of insurmountable physiological obstacles in the way of targeting,the development of efficient drug delivery systems for anti-fibrotics seems vital.We have explored articles with a different perspective on liver fibrosis over the two decades,then collected and summarized the information by providing corresponding in vitro and in vivo cases.We have discussed the mechanism of hepatic fibrogenesis with different ways of fibrosis induction in animals.Furthermore,the critical chemical and herbal anti-fibrotics,biological molecules such as micro-RNAs,siRNAs,and growth factors,which can affect cell division and differentiation,are mentioned.Likewise,drug and gene delivery and therapeutic systems on in vitro and in vivo models are summarized in the data tables.This review article enlightens recent advances in emerging drugs and nanocarriers and represents perspectives on targeting strategies employed in liver fibrosis treatment.