Tranexamic Acid and Ethamsylate for Reducing Blood Loss in Patient Undergoing Lower Segment Cesarean Section at High Risk for Post-Partum Hemorrhage: A Pilot Study

• 作者: Marwan M. Gamal
• 来源期刊: 妇产科期刊(英文)
• 学科: 数学
• 关键词: Blood Loss Postpartum Hemorrhage Elective Cesarean Delivery Tranexam-ic Acid Ethamsylate
• 年，卷（期）: 2020,（9）
• 页码范围: 1340-1350
• 页数: 11页
• 分类号: O17

摘要

<strong>Objective:</strong><span style="font-family:""><span style="font-family:Verdana;"> To assess the efficacy of intravenous tranexamic acid and ethamsylate in reducing blood loss during and after elective lower segment cesarean delivery in patients at high risk for postpartum hemorrhage. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">A double-blind, randomized placebo-controlled study was undertaken of women undergoing elective lower-segment cesarean delivery of a full-term pregnancy at high risk for postpartum hemorrhage at Ain Sham University Maternity Hospital in Cairo, Egypt, between January 2019 and October 2019. Patients were randomly assigned (1:1) using computer-generated random numbers to receive either 1 g tranexamic acid and 1 gm ethamsylate or 5% glucose (placebo) just after delivery of the fetus. Prophylactic oxytocin was administered to all women. Preoperative and postoperative complete blood count, hematocrit values, and maternal weight were used to calculate the estimated blood loss (EBL) during the cesarean, which was the primary outcome. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> Analyses included 32 women in each group. Our results showed that tranexamic acid and ethamsylate significantly reduced bleeding during and after cesarean delivery. The study group’s total blood loss (149.22 ±</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">54.74</span><span style="font-family:""> </span><span style="font-family:Verdana;">ml) was significantly less than the control group (353.75 ±</span><span style="font-family:""> </span><span style="font-family:Verdana;">115.56 ml) (p < 0.001). In our study, postoperative hemoglobin and hematocrit were significantly higher in the study group than </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">control group (p < 0.001);Reduction in hemoglobin and hematocrit were significantly