Keeping innate immune response in check:when cGAS meets the nucleosome

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2020,（12）
• 所属期刊栏目: RESEARCH HIGHLIGHTS
• 页码范围: 1055-1056
• 页数: 2页
• 语种: 英文

摘要

Cao et al.report on cryo-EM structures of human cyclic GMP-AMP synthase(cGAS)sensor bound to the nucleosome core particle,thereby defining the molecular mechanism of how cGAS avoids activation by chromatinized self-DNA,Notably,disruption of cGAS dimer formation and prevention of dsDNA recognition by the sensor at the nucleosome level impede cGAS activation.