Regio-Divergent C—H Alkynylation with Janus Directing Strategy via Ir(Ⅲ) Catalysis

• 作者: Guangxin Liang Xianwei Li Zhang-Jie Shi
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2020,（9）
• 所属期刊栏目: Breaking Reports
• 页码范围: 929-934
• 页数: 6页
• 语种: 英文
• DOI: 10.1002/cjoc.202000204

摘要

Directing strategy has been extensively exploited to maintain activity and selectivity for the rapid access to functionalized molecules and pharmaceutical targets.However,'one-to-one'activation model was usually achieved through traditional directing strategy.Herein,we achieved'one-to-two'activation model by slight modification of simple and practical ketoxime and amide functionality.With judicious choice of directing groups,Csp3—H and Csp2—H bond alkynylation reaction,and more significantly,dehydrogenative Csp3—H alkynylation,were realized,enabling the regio-divergent late-stage modifications of pharmaceuticals.