Tunable/reconfigurable metasurfaces that can actively control electromagnetic waves upon external stimuli are of great importance for practical applications of metasurfaces.Here,we demonstrate a reconfigurable nano-kirigami metasurface driven by pneumatic pressure operating in the near-infrared wavelength region.The metasurfaces consist of combined Archimedean spirals and are fabricated in a free-standing gold/silicon nitride nanofilm by employing focused ion beam(FIB)lithography.The deformable spirals are instantly transformed from two dimensional(2 D)to three-dimensional(3 D)by the FIB-based nano-kirigami process.The 2 D–to–3 D transformation induces a dramatic irreversible change of the plasmonic quadruple modes and results in significant modulation in reflection by 137%.The suspended porous nano-kirigami metasurface is further integrated with an optofluidics device,with which the optical resonance is reversibly modulated by the pneumatic pressure.This work provides a strategy for tunable/reconfigurable metasurfaces,which are useful to build a promising lab-ona-chip platform for microfluidics,biological diagnostics,chemical sensing,and pressure monitoring.