Convergent genomic signatures of high-altitude adaptation among domestic mammals

• 作者: Ali Esmailizadeh Cui-Ping Yang Da-Wei Yan David M Irwin Dong-Dong WU Hai-Bing Xie Hai-Peng Li He-Qun Liu Kun-Zhe Dong Li-Ping Jiang Lin Zeng Ming Li Ming-Shan Wang Peng Shi Qiu-Shuo Shen Shu-Li Yang Shu-Zhou Chu Song-Qing Fan Wen Wang Xiao Gou Xiao Xiao Xiao-Yan Kong Xin-Xing Dong Ya-Ping Zhang Yan Li Yang Dong Yong-Bin Chen Yue-Hui Ma Yun-Fei Ma Zi-Qian Hao
• 来源期刊: 国家科学评论（英文版）
• 关键词: high altitude Tibetan Plateau genome convergent evolution domestic animals
• 年，卷（期）: 2020,（6）
• 页码范围: 952-963
• 页数: 12页
• 语种: 英文
• DOI: 10.1093/nsr/nwz213

摘要

Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence.Here,we used 327 genomes from horses,sheep,goats,cattle,pigs and dogs living at both high and low altitudes,including 73 genomes generated for this study,to disentangle the genetic mechanisms underlying local adaptation of domestic mammals.Although molecular convergence is comparatively rare at the DNA sequence level,we found convergent signature of positive selection at the gene level,particularly the EPAS1 gene in these Tibetan domestic mammals.We also reported a potential function in response to hypoxia for the gene C10orff67,which underwent positive selection in three of the domestic mammals.Our data provide an insight into adaptive evolution of high-altitude domestic mammals,and should facilitate the search for additional novel genes involved in the hypoxia response pathway.