Palmitoylation of AMPA Receptors is Involved in the Inhibition of Hippocampal Long-term Potentiation by Aluminum Exposure in Rats

• 作者: GAO Ting LU Xiao Ting SONG Jing WANG Lin Ping XIA Xin Yu YUAN Chun Man ZHANG Hui Fang
• 来源期刊: 生物医学与环境科学（英文版）
• 年，卷（期）: 2020,（12）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 959-963,后插1,封3
• 页数: 7页
• 语种: 英文
• DOI: 10.3967/bes2020.133

摘要

Aluminum (Al) is the most abundant metal in the Earth's crust and is widely used in everyday life and industry. Al is neurotoxic to mammals. Epidemiological studies have confirmed the positive relationship between an increased environmental Al concentration and cognitive impairment[1]. Hippocampal long-term potentiation (LTP) has been widely used as a neuronal model of synaptic plasticity in experiments designed to elucidate the synaptic mechanisms involved in the loss of learning and memory[2]. The alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptor (AMPAR), a major glutamate-gated ion channel in the mammalian central nervous system, plays important roles in synaptic transmission, synaptic plasticity such as LTP, and learning and memory cognitive function of the brain. LTP typically results from an increased concentration of AMPARs at the postsynaptic membrane surface[3].