Palladium-Catalzyed Atroposelective 16-Membered Macrocyclization:Total Synthesis of Isoplagiochin D

• 作者: Junwei Xi Zhenhua Gu
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2020,（10）
• 所属期刊栏目: Concise Reports
• 页码范围: 1081-1085
• 页数: 5页
• 语种: 英文
• DOI: 10.1002/cjoc.202000051

摘要

Isoplagiochin D is a ring-strained macrocyclic bisbibenzylis,which showed stable axial chirality in one biaryl structure,and semistable axial chirality in the other biaryl moiety.We reported here an unprecedented example for the catalytically asymmetric synthesis of ring-strained atropisomers via Pd-catalyzed macrocyclization between benzyl halides and carbenes.This newly developed Pd-catalyzed asymmetric macrocyclization protocol enabled us a quick synthesis of isoplagiochin D in a highly enantioselective manner.