Copper-Catalyzed Carbocyclization of Silyl Enol Ether Tethered Ynamides for Efficient and Practical Synthesis of 2-Azabicyclo[3.2.0] Compounds

• 作者: En-He Huang Long-Wu Ye Peng-Cheng Qian Si-Han Ye Wen-Feng Luo Yang-Bo Chen Zhi-Xin Zhang
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2020,（10）
• 所属期刊栏目: Concise Reports
• 页码范围: 1086-1090
• 页数: 5页
• 语种: 英文
• DOI: 10.1002/cjoc.202000218

摘要

An effiicient copper-catalyzed carbocyclization of silyl enol ether tethered ynamides has been deVeloped,allowing rapid and practical construction of diverse 2-azabicyclo[3.2.0]compounds in generally good to excellent yields with broad substrate scope under mild reaction conditions.Importantly,this protocol not only constitutes a rare example of non-noble metal-catalyzed alkyne carbocyclization,but also represents a rare cyclization on the β-position of π-tethered ynamides.The possibility of asymmetric carbocyclization via kinetic resolution also emerges.