Construction of Alkenyl-Functionalized Spirocarbocyclic Scaffolds from Alkyne-Containing Phenol-Based Biaryls via Sequential Iodine-Induced Cyclization/Dearomatization and Pd-Catalyzed Coupling of N-Tosylhydrazones

• 作者: Anjia Liu Kaiming Han Xin-Xing Wu Shufeng Chen Jianbo Wang
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2020,（11）
• 所属期刊栏目: Concise Reports
• 页码范围: 1257-1262
• 页数: 6页
• 语种: 英文
• DOI: 10.1002/cjoc.202000170

摘要

An efficient strategy for the formation of alkenyl-functionalized spirocarbocyclic scaffolds from al-kyne-containing phenol-based biaryls via sequential iodine-induced cyclization/dearomatization and Pd-catalyzed coupling of N-tosylhydrazones is devel-oped.The approach provides various spirocarbocyclic compounds in moderate to excellent yields with good functional tolerance.The results also demonstrate the feasibility for the direct cross-couplings of N-tosylhydrazones with sterically congested tetrasubstituted alkenyl halides.