Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclobutanes

• 作者: Xiang Chen Lili Chen Hongliang Zhao Qian Gao Zhenlu Shen Senmiao Xu
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2020,（12）
• 所属期刊栏目: Concise Reports
• 页码范围: 1533-1537
• 页数: 5页
• 语种: 英文
• DOI: 10.1002/cjoc.202000240

摘要

We herein report the first example of iridium-catalyzed enantioselective C(sp3)-H borylation of cyclo-butanes using benzoxazoline as the directing group.The combination of a chiral bidentate boryl ligand and an iridium precursor has found to effectively catalyze C(sp3)-H borylation to afford a variety of cyclobutylboronates with good to excellent enantioselectivities.We also demonstrate the synthetic utilility of the current method by converting the stereogenic C-B bond to other functionalities.