Efficient Mimics for Elucidating Zaxinone Biology and Promoting Agricultural Applications

• 作者: Jian You Wang Muhammad Jamil Pei-Yu Lin Tsuyoshi Ota Valentina Fiorilli Mara Novero Randa A. Zarban Boubacar A. Kountche Ikuo Takahashi Claudio Martínez Luisa Lanfranco Paola Bonfante Angel R. de Lera Tadao Asami Sali Al-Babili
• 来源期刊: 分子植物（英文版）
• 年，卷（期）: 2020,（11）
• 所属期刊栏目: Research Reports
• 页码范围: 1654-1661
• 页数: 8页
• 语种: 英文

摘要

Zaxinone is an apocarotenoid regulatory metabolite required for normal rice growth and development.In addition,zaxinone has a large application potential in agriculture,due to its growth-promoting activity and capability to alleviate infestation by the root parasitic plant Striga through decreasing strigolactone(SL)production.However,zaxinone is poorly accessible to the scientific community because of its labo-rious organic synthesis that impedes its further investigation and utilization.In this study,we developed easy-to-synthesize and highly efficient mimics of zaxinone(MiZax).We performed a structure-activity rela-tionship study using a series of apocarotenoids distinguished from zaxinone by different structural fea-tures.Using the obtained results,we designed several phenyl-based compounds synthesized with a high-yield through a simple method.Activity tests showed that MiZax3 and MiZax5 exert zaxinone activity in rescuing root growth of a zaxinone-deficient rice mutant,promoting growth,and reducing SL content in roots and root exudates of wild-type plants.Moreover,these compounds were at least as efficient as zax-inone in suppressing transcript level of SL biosynthesis genes and in alleviating Striga infestation under greenhouse conditions,and did not negatively impact mycorrhization.Taken together,MiZax are a prom-ising tool for elucidating zaxinone biology and investigating rice development,and suitable candidates for combating Striga and increasing crop growth.