Pestaloamides A and B, two spiro-heterocyclic alkaloid epimers from the plant endophytic fungus Pestalotiopsis sp.HS30

• 来源期刊: 中国科学：化学（英文版）
• 年，卷（期）: 2020,（9）
• 所属期刊栏目: ARTICLES
• 页码范围: 1208-1213
• 页数: 6页
• 语种: 英文

摘要

Pestaloamides A and B (1 and 2),two novel alkaloids featuring an unprecedented spiro[imidazothiazoledione-alkylidenecyclopentenone]scaffold,were obtained from the cultures of an endophytic fungus Pestalotiopsis sp.HS30 which inhabited the stems ofIsodon xerophilus.Their planar structures and absolute configurations were fully determined by extensive spectroscopic analysis and X-ray crystallography.In addition,both compounds 1 and 2 showed the latent tumor immunotherapy activity through markedly promoting the cell surface engagement ofNKG2D ligands involving MICA/B and ULBP1 in HCT116 cells.